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TITANATE-BASED NANOSTRUCTURE FOR REGENERATION AND TISSUE ENGINEERING
专利权人:
UNIVERSITE DE BOURGOGNE;NVH MEDICINAL
发明人:
NADINE MILLOT,DAVID VANDROUX,VANESSA BELLAT
申请号:
FR1260998
公开号:
FR2998179B1
申请日:
2012.11.20
申请国别(地区):
FR
年份:
2015
代理人:
摘要:
The invention relates to a titanate nanoribbon nanostructure. The titanate nanoribbons have bioactive agents grafted onto the surface thereof via a bifunctional binding molecule, preferably a heterobifunctional polymer. The bifunctional polymer has, on one end, a functional grouping enabling said bifunctional polymer to be covalently grafted onto the surface of the titanate nanoribbons and moreover has, on the other end, a functional grouping enabling said bifunctional polymer to be covalently grafted to the bioactive agents. The titanate nanoribbon nanostructures, on which adhesive proteins (specifically, the proteins from the extracellular matrix, such as collagens, fibronectin, laminin, elastin, or any protein or peptide derived from the latter, for example the RGD peptide) are grafted, are particularly important for assisting the healing and regeneration processes of damaged tissues.
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