CHUNG, Chong-Pyoung,정종평,PARK, Yoon-Jeong,박윤정,LEE, Jue-Yeon,이주연,SHIM, In Kyong,심인경,PARK, Hyun Jung,박현정
申请号：
KRKR2012/002895
公开号：
WO2012/144778A9
申请日:
2012.04.17
申请国别(地区):
WO
年份:
2013
代理人:
摘要：
The present invention relates to a barrier membrane to which a peptide, which binds to collagen and which is capable of regenerating bone tissue, is bound. More particularly, the present invention relates to a collagen barrier membrane in which a fusion peptide consisting of a collagen-bound peptide and a functional bone-tissue-regenerating peptide is fixed to the surface of collagen. According to the present invention, the surface-active collagen barrier membrane, in which a fusion peptide is coupled to the surface of collagen, can stably bind to the body due to increased local retention, and promote the transport, proliferation, and differentiation of cells, to thereby ultimately maximize bone-tissue-regenerating capacity when implanted in the body. Therefore, the barrier membrane of the present invention is useful in the development of guided bone-regeneration technology. In addition, a fusion peptide can be applied to implants made of collagen having other shapes, and a collagen-bound peptide, which constitutes the fusion peptide, can be bound to and synthesized with a peptide having effects in regenerating other tissue, and therefore can be useful in tissue-regenerating biomaterials for other purposes, e.g. for regenerating skin.La présente invention concerne une membrane barrière à laquelle un peptide, qui se lie au collagène et qui est apte à régénérer un tissu osseux, est lié. Plus particulièrement, la présente invention concerne une membrane barrière au collagène dans laquelle un peptide hybride, consistant en un peptide lié au collagène et en un peptide fonctionnel de régénération de tissu osseux, est fixé à la surface du collagène. Conformément à la présente invention, la membrane barrière au collagène suractif, dans laquelle un peptide hybride est couplé à la surface du collagène, peut se lier de façon stable au corps, en raison de la plus grande rétention locale, et peut favoriser le transport, la prolifération et la différenciation de cellules, permett
