KELLY, MICHAEL,XU, SHIMIN,XI, NING,TOWNSEND, ROBERT,SEMIN, DAVID,GHIRON, CHIARA,COUTLER, THOMAS
申请号：
ES03736701
公开号：
ES2378759T3
申请日:
2003.05.23
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Compound or salt having the structure of formula (II): in which: R1 is Rb； R2 is C1-8 alkyl or C1-4 haloalkyl； R3 is H, C1-4 haloalkyl or C1-8 alkyl； R4 is H, C1-4 haloalkyl or C1-8 alkyl； R5 is, independently, in each case, H, C1-8 alkyl, C1-4 haloalkyl, halogen, -O-C1-6 alkyl, -NRaRd or NRdC (= O) Rd； R6 is Rd, C1-4 haloalkyl, -C (= O) Rc, -O-C1-6 alkyl, -ORb, -NRaRa, -NRaRb, -C (= O) ORc, -C (= O) NRaRa, OC (= O) Rc, -NRaC (= O) Rc, cyano, nitro, -NRaS (= O) mRc or -S (= O) mNRaRa； R7 is Rd, C1-4 haloalkyl, -C (= O) Rc, -O-C1-6 alkyl, -ORb, -NRaRa, -NRaRb, -C (= O) ORc, -C (= O) NRaRa, OC (= O) Rc, -NRaC (= O) Rc, cyano, nitro, -NRaS (= O) mRc or -S (= O) mNRaRa； or R6 and R7 together form a saturated or unsaturated bridge of 3 to 6 atoms containing 0, 1, 2 or 3 atoms of N and 0, 1 or 2 atoms selected from S and O, in which the bridge is substituted with 0 , 1 or 2 substituents selected from R5； wherein when R6 and R7 form a benzo bridge, then the benzo bridge can be additionally substituted with a bridge of 3 or 4 atoms containing 1 or 2 atoms selected from N and O, in which the bridge is substituted with 0 or 1 substituents selected from C1-4 alkyl； Ra is, independently, in each case, H, C1-4 haloalkyl or C1-6 alkyl； Rb is, independently, in each case, phenyl, benzyl, naphthyl or a saturated or unsaturated 5 or 6 membered ring heterocycle containing 1, 2 or 3 atoms selected from N, O and S, with no more than 2 of the atoms selected from O and S, in which the phenyl, benzyl or heterocycle are substituted with 0, 1, 2 or 3 substituents selected from C1-6 alkyl, halogen, C1-4 haloalkyl, -O-C1-6 alkyl, cyano and nitro； Rc is, independently, in each case, C1-6 alkyl, C1-4 haloalkyl, phenyl or benzyl； Rd is, independently, in each case, H, C1-6 alkyl, phenyl, benzyl or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from N, O and S, with no more than 2 of the atoms selected from O and S, wherein C1-6 alkyl, phenyl, ben
