The present invention is concerned with indolin-2-one derivatives of general formulawherein the substituents are defined in claim 1. The compounds may be used in the treatment of CNS diseases related to positive (psychosis) and negative symptoms of schizophrenia, substance abuse, alcohol and drug addiction, obsessive-compulsive disorders, cognitive impairment, bipolar disorders, mood disorders, major depression, treatment resistant depression, anxiety disorders, Alzheimer's disease, autism, Parkinson's disease, chronic pain, borderline personality disorder, neurodegenerative disease, sleep disturbances, chronic fatigue syndrome, stiffness, inflammatory disease, asthma, Huntington's disease, ADHD, amyotrophic lateral sclerosis, effects in arthritis, autoimmune disease, viral and fungal infections, cardiovascular diseases, ophthalmology and inflammatory retinal diseases and balance problems, epilepsy and neurodevelopmental disorders with co-morbid epilepsy.本發明係關於具有以下通式之吲哚啉-2-酮衍生物：， 其中取代基如請求項1中所定義。 該等化合物可用於治療與精神分裂症之陽性(精神病)及陰性症狀相關之CNS疾病、藥物濫用、酒精及藥物成癮、強迫症、認知障礙、躁鬱症、情緒障礙、嚴重抑鬱症、治療抗性抑鬱症、焦慮症、阿茲海默氏病(Alzheimer's disease)、自閉症、帕金森氏病(Parkinson's disease)、慢性疼痛、邊緣型人格障礙、神經退化性疾病、睡眠紊亂、慢性疲勞症候群、僵硬、炎性疾病、哮喘、亨廷頓氏病(Huntington's disease)、ADHD、肌肉萎縮性側索硬化、關節炎的效應、自體免疫疾病、病毒及真菌感染、心血管疾病、眼科及炎性視網膜疾病及平衡問題、癲癇症及伴有併發症癲癇症之神經發育性病症。
