The present invention relates to a method for treating a condition selected from the group consisting of sexual dysfunction, emotional disorder, anxiety, depression, chronic fatigue, Tourettes syndrome, Angelmans syndrome, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), obesity, As an inhibitor of human dopaminergic transporter (DAT) protein for the treatment of motor disorders, CNS disorders, sleep disorders, sleep attacks, behavior disorders, substance abuse (including smoking cessation), eating disorders, and impulse control disorders To provide a compound of formula (I), in particular 2-[bis (4-fluorophenyl) methyl]-2,7-diazaspiro [4.5] decan-10-one derivative and related compounds.Embedded image Selection drawing None本発明は、性機能不全、感情障害、不安症、鬱病、慢性疲労、トゥレット症候群、アンジェルマン症候群、注意欠陥障害(ADD)、注意欠陥多動障害(ADHD)、肥満、疼痛、強迫性障害、運動障害、CNS障害、睡眠障害、睡眠発作、行為障害、物質乱用(禁煙を含む)、摂食障害、及び衝動制御障害の治療のための、ヒトドーパミン活性トランスポーター(DAT)タンパク質の阻害剤として、式(I)の化合物を提供し、特に、2-[ビス(4-フルオロフェニル)メチル]-2,7-ジアザスピロ[4.5]デカン-10-オン誘導体及び関連化合物を提供する。【化1】【選択図】 なし
