The present invention relates to a negative oxygen-therapy machine having a pool, a first motor, a second motor, a blending device, a ozone generator and a control system. The control system controls the first motor to pump the water in the pool into the blending device so that the water is blended with the ozone delivered from the ozone generator in the blending device. Then the control system controls the second motor to pump the water-oxygen mixture in the blending device back to the pool. With the zigzag mixing path in the blending device and continuous water cycle, the ozone is fully dissolved in the water and achieves the minimization. Thus, the user can carry out the ozone bath at room temperature and pressure.本發明為一種負壓氧療機，其包含有一浸泡池、一第一馬達、一第二馬達、一融合器、一臭氧產生器及一控制系統，該控制系統控制第一馬達運轉，以將浸泡池中的水打入融合器中，並與臭氧產生器所送入融合器中的臭氧加以混合，再由該控制系統控制第二馬達運轉，以將融合器中的水氣混合體打回浸泡池中，透過融合器中彎曲的水氣混合路徑，以及不斷的水循環作用下，使得臭氧充分溶解於水中並使分子細緻化，而讓使用者得以於常溫常壓下進行臭氧浴。
