MICHAEL GALLUPPI,ガルッピ，マイケル,SCOTT BROWN,ブラウン，スコツト,PETER A BASILE,バジル，ピーター・エー,ガルッピ,マイケル,ブラウン,スコツト,バジル,ピーター・エー
申请号：
JP2014233887
公开号：
JP2015051309A
申请日:
2014.11.18
申请国别(地区):
JP
年份:
2015
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide a polyflux collider arrangement for a dry powder dispenser capable of providing a higher fine particle fraction that can be targeted to the desired area of the lung and also capable of providing a higher total amount of drug that can be administered.SOLUTION: A polyflux collider arrangement that can be used in conjunction with a powder dispenser comprises a polyflux collider 32 having a body 30 at least partially encompassing a volume part and a single exit opening 42, the first inlet opening 44 and second inlet opening 46 and the exit opening being in communication with the encompassed volume part, and the exit opening being spaced from the reference plane. Upon inhalation of a dose, negative pressure is applied to the exit opening which causes a first stream of dry powder to be entrained from the first inlet opening into the encompassed volume part and directed toward the exit opening. The negative pressure also causes a second stream of dry powder to be entrained from the second inlet opening into the encompassed volume part and directed toward the exit opening.【課題】多い微粒子割合で、肺の望ましい部位を標的にし、かつ、より多い薬物の総量を投与することができる乾燥粉末投与器のためのポリフラックスコライダ配置体を提供する。【解決手段】粉末投与器と共に使うことができるポリフラックスコライダ配置体は、容積部を少なくとも部分的に取り囲む本体３０と単一の出口開口部４２とを有し、第１の入口開口部４４および第２の入口開口部４６と出口開口部とが取り囲まれた容積部と連通し、出口開口部が基準面から離間しているポリフラックスコライダ３２を備え、１回分の用量の吸入時に、乾燥粉末の第１の流れを第１の入口開口部から取り囲まれた容量部へ引き込み、出口開口部の方へ導く負圧が出口開口部に加えられる。この負圧は、同様に、乾燥粉末の第２の流れを第２の入口開口部から取り囲まれた容積部へ引き込み、出口開口部の方へ導く。【選択図】図１
