PROBLEM TO BE SOLVED: To provide a prodrug including an NO-releasing prodrug a double prodrug, and mutual prodrug, in which bio-cleavable linker and a remedy are linked covalently.SOLUTION: There is provided a compound of formula (I) or a pharmaceutically acceptable salt thereof. [In the formula, (a) represents O B represents S-S A and A1 each independently represents (CH2)d d represents 1-4 D1 represents a remedy including -OH, -SH, -CO2H or the like D2 independently represents D1, a peptide, a protein, a monoclonal antibody, a vitamin, an amino acid or the like E represents CH2 or a bond and L1 and L2 each independently represents a bond, O, S or the like].COPYRIGHT: (C)2013,JPO&INPIT【課題】バイオ開裂性リンカーと治療薬が共有結合しているNO放出プロドラッグ、ダブルプロドラッグおよび相互プロドラッグを含むプロドラッグを提供する。【解決手段】下式(I)の化合物またはその薬剤的に容認できる塩。[式中、aは0を表し、BはS-Sを表し、AおよびA1は独立して(CH2)dを表し、dは1~4であり、D1は、-OH、-SH、-CO2H等を含んでなる治療薬を表し、D2は独立してD1、ペプチド、タンパク質、単クローン抗体、ビタミン、アミノ酸等を表し、EはCH2または結合を表し、L1およびL2は独立して結合、O、S等を表す。]【選択図】なし
