A controlled released sealing capsule in gastrointestinal tract including stomach, duodenum, jejunum, ileum and colon includes a hole-containing capsule shell and a temporary sealing substance. The hole-containing capsule shell has one or more holes. The temporary sealing substance is disposed in at least one of the one or more holes and configured to go away from the hole when the sealing capsule is in a target-portion of the gastrointestinal tract.一種胃腸道(胃、十二指腸、空腸、迴腸及大腸)控制釋放之封孔膠囊,包括含孔膠囊殼及暫時性封孔物質。含孔膠囊殼具有一或多個孔洞。暫時性封孔物質設置於一或多個孔洞之至少一者內,當封孔膠囊位於胃腸道之一特定部分內時,暫時性封孔物質用以離開孔洞。10‧‧‧含孔膠囊殼10a‧‧‧孔洞12‧‧‧頭部14‧‧‧身部20‧‧‧暫時性封孔物質D1‧‧‧含孔膠囊殼之直徑D2‧‧‧孔洞之直徑
