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TAILORED LIPOSOMES FOR THE TREATMENT OF BACTERIAL INFECTIONS
专利权人:
UNIVERSITAET BERN
发明人:
Eduard Babiychuk,Annette Draeger
申请号:
US14404985
公开号:
US20150157570A1
申请日:
2013.06.13
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The invention relates to the use of empty liposomes of defined lipid composition or mixtures of empty liposomes of defined lipid composition and to the use of other lipid bilayers or monolayers of defined lipid composition for the treatment and prevention of bacterial infections. It has been found that such liposomes, in particular a two- and a four-component mixture of liposomes comprising cholesterol and sphingomyelin, liposomes consisting of sphingomyelin, liposomes comprising sphingomyelin and phosphatidylcholine, and liposomes comprising cholesterol and phosphatidylcholine efficiently sequestrate a variety of toxins secreted by bacteria, thus preventing binding of bacterial toxins to target cells and toxin-induced lysis of the target cells. Injected intravenously, liposome mixtures prevented death of laboratory mice infected with lethal doses of Staphylococcus aureus or Streptococcus pneumoniae.
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