Kurt Roinestad,William Guilford,Tom Kirkland,Lopa Bhatt,Eric Springman
申请号：
US15838012
公开号：
US10202334B2
申请日:
2017.12.11
申请国别(地区):
US
年份:
2019
代理人:
摘要：
This present disclosure is directed to compounds of formula (I):where R1a, R1b, R1c, R1d, R1e, R3, R4a, R4b, R4c, R4d, R6, R7, and R8 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof； which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions including the compounds described herein and methods of preparing the compounds described herein are also provided.
