The device includes a manipulation mechanism for maneuvering a base into position proximate a subcutaneous port. Arms extending from the base enable the device to receive the port and substantially immobilize the port relative to the device. The manipulation mechanism also enables a user to substantially immobilize the device relative to a patient. With the subcutaneous port substantially immobilized by the device, the user has greater confidence and accuracy when inserting a needle into the port. Further, embodiments of the device provide protection to the user to prevent inadvertent sticking of the user as the needle is introduced.