A guide for dental interproximal reduction, the guide including a tray shaped to substantially conform to one or more teeth, wherein the tray holds at least one of the one or more teeth stationary during the interproximal reduction； one or more grooves in the tray, each groove positioned to allow access to an interproximal space between a first tooth and a second tooth； and a first lateral edge in each of the one or more grooves, wherein the first lateral edge is shaped to guide an instrument for interproximal reduction of the first tooth.
