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Agomelatine hydrochloride hydrate and preparation thereof
专利权人:
LES LABORATOIRES SERVIER
发明人:
ZHU XUEYAN,YUAN ZHEDONG,YU XIONG,SHAN HANBIN,ZHANG PENG,PAN HONGJUAN
申请号:
NZ60245011
公开号:
NZ602450A
申请日:
2011.03.17
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
Disclosed is crystalline agomelatine hydrochloride monohydrate as represented by general formula (I), wherein X is Cl. Further disclosed is a method for the preparation of agomelatine hydrochloride monohydrate, wherein agomelatine is reacted with hydrochloric acid in an aqueous organic solvent to produce the agomelatine hydrochloride hydrate. Also disclosed is a pharmaceutical composition, comprising an agomelatine hydrochloride hydrate as defined above in associated with one or more pharmaceutically acceptable adjuvants or excipients.
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