This application involves the cells that genome is modified, the modification makes more to reduce or disappear compared with its parental cell to sugar chain modified relevant enzymatic activity, in the modification, in the sugar chain complex of N- glucosides connection 1 of fucose with 6 of the N-acetylglucosamine of reducing end by α-key connection, and with the method for cell generation antibody compositions.本申請涉及基因組被修飾的細胞，所述的修飾使與糖鏈修飾相關的酶活性較其親代細胞更降低或消失，在所述修飾中，N-糖苷連接的糖鏈複合體中岩藻糖的1位與還原端的N-乙酰氨基葡萄糖的6位在通過α-鍵連接，以及用該細胞産生抗體組合物的方法。
