Methods for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis with (−)-nilvadipine enantiomers

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专利权人:

アルツハイマーズ・インスティテュート・オブ・アメリカ・インコーポレイテッド

发明人:

マイケル・ジェイ・ムラン,ダニエル・パリ,ロバート・エイ・アイビー・ザ・サード

申请号：

JP2010528172

公开号：

JP5411145B2

申请日:

2008.10.03

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The present invention provides methods for reducing A&bgr； deposition, A&bgr； neurotoxicity and microgliosis in an animal or human afflicted with a cerebral amyloidogenic disease, such as Alzheimer's disease (AD), by administering therapeutically effective amounts of the (R)-enantiomer of the dihydropyridine compound nilvadipine, also known as (&minus；)-nilvadipine, to the animal or human. Further provided are methods for reducing the risk of A&bgr； deposition, A&bgr； neurotoxicity and microgliosis in animals or humans suffering from traumatic brain injury by administering (&minus；)-nilvadipine after the traumatic brain injury and continuing treatment for a prescribed period of time thereafter.

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