MULLAN, MICHAEL, J.,PARIS, DANIEL,IVEY, ROBERT, A., III
申请号：
DK08836256
公开号：
DK2214666T3
申请日:
2008.10.03
申请国别(地区):
DK
年份:
2014
代理人:
摘要：
The present invention provides methods for reducing A&bgr； deposition, A&bgr； neurotoxicity and microgliosis in an animal or human afflicted with a cerebral amyloidogenic disease, such as Alzheimer's disease (AD), by administering therapeutically effective amounts of the (R)-enantiomer of the dihydropyridine compound nilvadipine, also known as (&minus；)-nilvadipine, to the animal or human. Further provided are methods for reducing the risk of A&bgr； deposition, A&bgr； neurotoxicity and microgliosis in animals or humans suffering from traumatic brain injury by administering (&minus；)-nilvadipine after the traumatic brain injury and continuing treatment for a prescribed period of time thereafter.
