A method and system for self-contained growth and harvesting of plant and animal foodstuffs and energy generation for terrestrial and non-terrestrial uses. The system can be self-contained and sealed from an ambient atmosphere wherein sufficient oxygen and carbon dioxide levels are maintained (bio-regenerative) to support human life. The system and method may utilize aquaculture and hydroponic plant growth with a digester for converting waste into nutrients. Water may circulate among the digester, aquaculture tanks and hydroponic growth tanks. The method may be scalable to support varying quantities of human life. The system and method may generate energy and consume greater quantities of carbon dioxide than generated. The system may be energy self-sufficient utilizing solar, wind or other energy sources such as generated methane gas.