University of Pittsburgh of the Commonwealth System of Higher Education;The Regents of the University of California
发明人:
Hedrick, Marc H.,Katz, Adam J.,Llull, Ramon,Futrell, William J.,Benham, Prosper,Lorenz, Hermann Peter,Zhu, Min
申请号：
AU2008202757
公开号：
AU2008202757B8
申请日:
2008.06.20
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2008202757B820120906.pdf#####P: WPDOCS CRN XJ Spc 20408581 abstact doc- 1/06/2008 ABSTRACT The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the 5 ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide 10 conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures. 15
