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METHOD FOR TREATING CANCER BASED ON METALLOFULLERENE MONOCRYSTALLINE NANOPARTICLES THAT SPECIFICALLY DISRUPT TUMOR BLOOD VESSELS
专利权人:
Beijing Fullcan Bio-technology Co.; Ltd.
发明人:
Chunru WANG,Mingming ZHEN,Chunying SHU,Taishan WANG,Jie LI,Guoqiang ZHANG
申请号:
US16837953
公开号:
US20200246458A1
申请日:
2020.04.01
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Metallofullerene monocrystalline nanoparticles are used as tumor vascular disrupting agents. The monocrystalline nanoparticles are water-soluble metallofullerene nanoparticles with negative charges on their surfaces. The particle sizes range from 50 to 250 nanometers. The nanomaterials are able to absorb outside radiation energy, and transform it into heat energy. The volumes rapidly expand when temperature reaches a phase transformation point. For treatment, metallofullerene monocrystalline nanoparticles are administrated to a tumor-bearing organism via injection. The metallofullerene monocrystalline nanoparticles reach tumor sites via blood circulation, and are retained at the tumor sites. The monocrystalline nanoparticles of metallofullerene accumulate heat and the temperature increases under outside radiation energy. The volumes sharply expand when the temperature exceeds a critical point of phase transition thereof, thereby causing changes in the morphologies, structures or functions of endothelium cells of tumor vessels.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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