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Triazolopyridine compounds as pde10a inhibitors
专利权人:
F. Hoffmann-La Roche AG
发明人:
FLOHR, Alexander,GROEBKE ZBINDEN, Katrin,KOERNER, Matthias
申请号:
ES12759445
公开号:
ES2626801T3
申请日:
2012.09.17
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula (I) ** Formula ** in which R 1 is aryl, heteroaryl or NR 4 R 5, wherein said aryl and said heteroaryl may be substituted with 1 to 3 substituents independently selected from the group consisting of hydroxyl, halogen, C1-C7 alkyl, C1-C7 alkoxy and C1-C7 haloalkyl; R2 is hydrogen, halogen or C1-C7 alkyl; R3 is aryl or heteroaryl, wherein said aryl and said heteroaryl may be substituted with 1 to 3 substituents independently selected from the group consisting of C1-C7 alkyl, hydroxyl, halogen, -C (O) -NR6R7 and -C (O ) -O-R8; R4 and R5 are independently C1-C7 alkyl, C3-C8 cycloalkyl, together with the nitrogen atom to which they are attached, form a heterocycloalkyl which may be substituted with 1 to 3 substituents independently selected from the group consisting of hydroxyl, halogen, alkyl C1-C7, C1-C7 alkoxy and C1-C7 haloalkyl; R6 and R7 are independently C1-C7 alkyl, C3-C8 cycloalkyl, together with the nitrogen atom to which they are attached, form a heterocycloalkyl which may be substituted with 1 to 3 substituents independently selected from the group consisting of hydroxyl, halogen, alkyl C1-C7, C1-C7 alkoxy and C1-C7 haloalkyl; R8 is hydrogen, C1-C7 alkyl, cycloalkyl; or a pharmaceutically acceptable salt thereof.Un compuesto de fórmula (I) **Fórmula** en la que R1 es arilo, heteroarilo o NR4R5, en el que dicho arilo y dicho heteroarilo pueden estar sustituidos con 1 a 3 sustituyentes seleccionados independientemente del grupo que consiste en hidroxilo, halógeno, alquilo C1-C7, alcoxi C1-C7 y haloalquilo C1-C7; R2 es hidrógeno, halógeno o alquilo C1-C7; R3 es arilo o heteroarilo, en el que dicho arilo y dicho heteroarilo pueden estar sustituidos con 1 a 3 sustituyentes seleccionados independientemente del grupo que consiste en alquilo C1-C7, hidroxilo, halógeno, -C(O)-NR6R7 y - C(O)-O-R8; R4 y R5 son independientemente alquilo C1-C7, cicloalquilo C3-C8, junto con el átomo de nitrógeno al que están unidos, forman un heterocicloalquilo que p
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