The present invention has for object the use of minocycline or its equivalent forms, or any form of tetracycline in combination with acycloguanosine or any equivalent form (antiviral), atorvastatin or any equivalent form (lipophilic statins) and vitamin D3 (pro hormone) for the preparation of a single compound addressed to treatment of autoimmune type of rheumatoid arthritis in the three stages of development, whether it is active or quiescent phase or forms of diseases eziopatologicamente equivalent, but some degenerative. The efficacy of this combination has been proven by many studies on individual components. To date, given the proven effectiveness of the individual components, the low toxicity of the same and the long period of their marketing, as well as the observed higher efficiency of the combination of these used in accordance with the new mode overexposed, it can be said that the new compound abovementioned derived from a combination of minocycline or its equivalent forms, or any form of tetracycline in combination with acycloguanosine or any equivalent form (antiviral), atorvastatin or any equivalent form (lipophilic statins) and vitamin D3 (pro-hormone), is effective in reducing the incidence of the disease on quality of life of the patient, in particular with a certain dose level, before today never identified or determined.
