SUH, Hea Ran,서혜란,OH, Young Heun,오영흔,HAN, Sang Min,한상민,BAE, Min Hee,배민희,AN, Tae Kun,안태군,CHOI, Ju Huen,최주현,OH, Seung Youn,오승연,KIM, A Ram,김아람,KIM, Jong Min,김종민,AN, Gug Hwan,안국환,NAM, Yoon Jin,남윤진,JEON, Da
申请号：
KRKR2015/006771
公开号：
WO2016/021835A1
申请日:
2015.07.01
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a preparation method of drug-containing sustained release microparticles, the preparation method comprising the steps of: (a) dissolving a biodegradable polymer and a drug in a halogenated alkane solvent to form a drug-containing biodegradable polymer solution； (b) homogeneously mixing the drug-containing biodegradable polymer solution in a continuous phase containing a surfactant to form a dispersed phase； (c) maintaining an emulsion comprising the continuous phase and the dispersed phase at a temperature lower than the boiling point of the halogenated alkane solvent to form microparticles in the continuous phase； (d) primarily drying the microparticles； (e) mixing the primarily dried microparticles with an aqueous alcohol solution, and then maintaining the aqueous alcohol solution at a temperature no less than the boiling point of the halogenated alkane solvent to extract and evaporate the remaining halogenated alkane solvent from the microparticles； and (f) secondarily drying the obtained microparticles to produce drug-containing microparticles. The drug-containing sustained release microparticles prepared in accordance with the preparation method of the present invention minimize the hydrolysis of the biodegradable polymer in the microparticles, while easily removing the halogenated alkane solvent in the microparticles, and are thus capable of exhibiting excellent sustained drug release.La présente invention concerne un procédé de préparation d'une microparticule à libération prolongée contenant un médicament, le procédé de préparation comprenant les étapes consistant à : (a) dissoudre un polymère biodégradable et un médicament dans un solvant d'alcane halogéné pour former une solution de polymère biodégradable contenant le médicament； (b) mélanger de manière homogène la solution de polymère biodégradable contenant le médicament dans une phase continue contenant un tensioactif pour former une phase dispersée； (c) maintenir une ém
