KIM, Jeoung Yong,김정용,LEE, Won Chun,이원천,KANG, Mi Yeon,강미연,CHOI, Hang Je,최항제
申请号：
KRKR2020/000413
公开号：
WO2020/189886A2
申请日:
2020.01.09
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to biodegradable polymer microparticles containing a steroid-based drug and a preparation method therefor. Biodegradable polymer microparticles containing a steroid-based drug are prepared by a preparation method wherein: the steroid-based drug and a biodegradable polyester-based polymer are dissolved in a suitable organic solvent； the solution is sprayed into a low-temperature hydrocarbon solution to form frozen microparticles； and then the same microparticles are added to a low-temperature aqueous salt solution to dissolve the organic solvent contained in the microparticles. The biodegradable polymer microparticles containing a steroid-based drug or a sex hormone drug, which is a steroid-based drug, are found to have excellent biocompatibility, biodegradability, porosity, and mechanical strength and release the steroid-based drug or the sex hormone drug, which is a steroid-based drug, in a sustained manner for a long period of time, whereby the biodegradable polymer microparticles containing a steroid-based drug or a sex hormone drug, which is a steroid-based drug, according to the present invention are expected to develop a formulation that can treat a symptom or disease attributed to the reduction or depletion of a steroid or a sex hormone, which is a kind of steroid, by release the drug uniformly and continuously for a long period of time.La présente invention concerne des microparticules polymères biodégradables et un procédé de préparation associé. Des microparticules polymères biodégradables contenant un médicament à base de stéroïde sont préparées par un procédé de préparation dans lequel: le médicament à base de stéroïde et un polymère à base de polyester biodégradable sont dissous dans un solvant organique approprié； la solution est pulvérisée dans une solution d'hydrocarbures à basse température pour former des microparticules congelées； puis les mêmes microparticules sont ajoutées à une solution saline aqueuse à basse tempé
