Provided herein are recombinant fusion polypeptides comprising an HPV16 antigenic peptide and an HPV18 antigenic peptide, wherein the HPV16 antigenic peptide and the HPV18 antigenic peptide are operably linked in tandem (e.g., fused to a PEST- containing peptide). Also provided are nucleic acids encoding such fusion polypeptides, recombinant bacteria or Listeria strains comprising such fusion polypeptides or such nucleic acids, and cell banks comprising such recombinant bacteria or Listeria strains. Also provided herein are methods of generating such fusion polypeptides, such nucleic acids, and such recombinant bacteria or Listeria strains. Also provided are immunogenic compositions, pharmaceutical compositions, and vaccines comprising such fusion polypeptides, such nucleic acids, or such recombinant bacteria or Listeria strains. Also provided are methods of inducing an anti-tumor-associated-antigen immune response in a subject, methods of inducing an anti-tumor or anti-cancer immune response in a subject, methods of treating a tumor or cancer in a subject, methods of preventing a tumor or cancer in a subject, and methods of protecting a subject against a tumor or cancer using such recombinant fusion polypeptides, nucleic acids, recombinant bacteria or Listeria strains, immunogenic compositions, pharmaceutical compositions, or vaccines.L'invention concerne des polypeptides de fusion recombinés comprenant un peptide antigénique de HPV16 et un peptide antigénique de HPV18, le peptide antigénique de HPV16 et le peptide antigénique de HPV18 étant liés fonctionnellement en tandem (par exemple, fusionnés à un peptide contenant du PEST). La présente invention concerne également des acides nucléiques codant pour de tels polypeptides de fusion, des bactéries ou des souches de Listeria recombinées comprenant de tels polypeptides de fusion ou de tels acides nucléiques, et des banques cellulaires comprenant de telles bactéries ou souches de Listeria recombinées. La présente inv
