Provided herein are tumor-associated antigen peptides comprising heteroclitic mutations and fusion polypeptides comprising such heteroclitic peptide. Also provided are nucleic acids encoding such peptides and fusion polypeptides, recombinant bacteria or Listeria strains comprising such peptides, fusion polypeptides, or nucleic acids, and cell banks comprising such recombinant bacteria or Listeria strains. Also provided herein are methods of generating such peptides, fusion polypeptides, nucleic acids, and recombinant bacteria or Listeria strains. Also provided are immunogenic compositions, pharmaceutical compositions, and vaccines comprising such peptides, fusion polypeptides, nucleic acids, or recombinant bacteria or Listeria strains. Also provided are methods of inducing an anti-tumor-associated-antigen immune response in a subject, methods of inducing an anti-tumor or anti-cancer immune response in a subject, methods of treating a tumor or cancer in a subject, methods of preventing a tumor or cancer in a subject, and methods of protecting a subject against a tumor or cancer using such peptides, recombinant fusion polypeptides, nucleic acids, recombinant bacteria or Listeria strains, immunogenic compositions, pharmaceutical compositions, or vaccines.L'invention concerne des peptides antigéniques associés aux tumeurs comprenant des mutations hétéroclitiques et des polypeptides de fusion comprenant un tel peptide hétéroclitique. L'invention concerne également des acides nucléiques codant pour de tels peptides et de tels polypeptides de fusion, des bactéries ou des souches de Listeria recombinées comprenant de tels peptides, de tels polypeptides de fusion ou de tels acides nucléiques, et des banques cellulaires comprenant de telles bactéries ou souches de Listeria recombinées. L'invention concerne également des procédés de production de tels peptides, de tels polypeptides de fusion, de tels acides nucléiques et de telles bactéries ou souches de Listeria recombinées.
