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BIOMARQUEURS DE CANCER ET PROCÉDÉS D'UTILISATION
专利权人:
Agency for Science; Technology and Research
发明人:
LIM, Bing,ZHANG, Wencai,TAM, Wai Leong
申请号:
EP17779454
公开号:
EP3439669A4
申请日:
2017.04.06
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
The present disclosure relates to a method of determining the presence of lung cancer in a subject comprising the steps of detecting an expression level of miR-1246 alone or in combination with an expression level of miR-1290 in a sample obtained from the subject wherein the increase in miR-1246 and/or miR-1290 in the sample obtained from the subject relative to the expression level of miR-1246 or miR-1290 in the control sample indicates the presence of lung cancer in the subject. The disclosure further comprises a method of monitoring a response to therapy in a lung cancer patient, a method of prognosis of lung cancer in a patient and a method for treating lung cancer in a subject comprising the use of inhibitors of miR-1246 and/or miR-1290 alone or in combination. In a specific embodiment, miR-1246 and/or miR-1290 levels are used to predict response to chemotherapy and progression in human non-small cell lung cancer (NSCLC) patients.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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