A system for remote ischemic preconditioning, the system comprising:a cuff configured to retract about a limb of a subjectmeans to identify the subjects systolic pressurean actuator connected to the cuff and that, when actuated, causes the cuff to contract about the limb of the subject to reduce blood flow therethrough anda controller that controls the actuator according to a treatment protocol that takes into account the identified systolic pressure and includes a plurality of treatment cycles, each treatment cycle comprisingcuff actuation, during which the actuator contracts the cuff about the limb of the subject to a pressure above said identified systolic pressure to occlude blood flow through the limban ischemic duration, during which the actuator maintains the cuff contracted about the limb at a set point above said identified systolic pressure to occlude blood flow through the limb, the ischemic duration lasting for at least five secondscuff release, during which the actuator releases the cuff to allow blood flow through the limb anda reperfusion duration, during which the cuff is maintained about the limb in a relaxed state to allow blood flow through the limb, the reperfusion duration lasting for at least one minute.
