A system for remote ischemic conditioning and the system comprising: a cuff configured to retract about a limb of a subject an actuator connected to the cuff and that, when actuated and causes the cuff to contract about the limb of the subject to reduction blood flow therethrough a controller that controls the actuator according to a treatment protocol that includes a plurality of treatment cycles and each treatment cycle comprising cuff actuation and during which the actuator contracts the cuff about the limb of the subject to a pressure that occludes blood flow through the limb an ischemic duration, during which the actuator maintains the cuff contracted about the limb at a set point to occlude blood flow through the limb and the ischemic duration lasting for at least five seconds cuff release and during which the actuator releases the cuff to allow blood flow through the limb and a reperfusion duration, during which the cuff is maintained about the limb in a relaxed state to allow blood flow through the limb and the reperfusion duration lasting for at least one minute the system further comprising means by which a doctor can confirm the extent of subject compliance with said treatment protocol.
