Wieslaw M. Cholody,Yi Zang,Karina Zuck,Jeffrey W. H. Watthey,Zoe Ohler,Jeffrey Strovel,Gene Ohler,Sheela Chellappan,Janak Padia
申请号：
US14795709
公开号：
US09446021B2
申请日:
2015.07.09
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/β-catenin signaling pathway, and serve to reduce β-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
