Chemical agents, such as disulfonamide derivatives of fluorene, anthracene,xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures,including salts thereof, that act as anti-cancer and anti-tumor agents, especiallywhere such agents modulate the activity of the Wnt/β-catenin signalingpathway, and serve to reduce β-catenin levels present in cells, such ascancer cells, or where the agents modulate levels of gene expression in cellularsystems, including cancer cells, are disclosed, along with methods for preparingsuch agents, as well as pharmaceutical compositions containing such agentsas active ingredients and methods of using these as therapeutic agents.
