TGF-β抑制劑

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专利权人:

Rigel Pharmaceuticals, Inc.;Bristol-Myers Squibb Company

发明人:

KINSELLA, Todd,GELMAN, Marina,HONG, Hui,DARWISH, Ihab, S.,SINGH, Rajinder,YU, Jiaxin,BORZILLERI, Robert, M.,VELAPARTHI, Upender,LIU, Peiying,DARNE, Chetan,RAHAMAN, Hasibur,WARRIER, Jayakumar, Sankara

申请号：

HK18103172.4

公开号：

HK1244785A

申请日:

2018.03.06

申请国别(地区):

HK

年份:

2018

代理人:

摘要：

Disclosed are imidazole and thiazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure Formula (I) and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, A, Z, R1 and R' are as described herein. In certain embodiments, a compound disclosed herein inhibits TGF-β, and can be used to treat disease by blocking TGF-β signaling.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/