The present invention relates to a compound containing an oxygen-15 and a process for preparing thereof, use of the compound containing an oxygen-15 in the positron or the other nuclide imaging, use of the compound containing an oxygen-15 in obtaining its perfusion or metabolic imaging in an animal or human body. A process for preparing a compound containing an oxygen-15 is characterized by: utilizing irradiation energy in the range of 20 million electron volt (MeV) to 430 MeV generated by a high energy electron accelerator, a proton, a heavy ion or a neutron treatment device to irradiate on an oxygen containing compound (water for example) allowing an oxygen atom in the compound (water for example) to be converted to an oxygen-15 positron nuclide through a photonuclear reaction provided that the molecular structure of the irradiated compound is not disrupted, thereby preparing a compound containing an oxygen-15. When the compound of the present invention is injected into the body, the perfusion and metabolic situation in the body thereof are imaged perfectly. The compound of the present invention can be used for the nuclear medicine devices such as PET, PET-CT, PET-MRI, PET-MRI-CT.
