An antimicrobial peptide with heparin binding activity is described. It can be derived from endogenous mammalian proteins being substantially free from antimicrobial activity selected from the group consisting of laminin isoforms, complement factor C3, histidin rich glycoprotein and kininogen and having from 10 to 36 amino acids residues, wherein the antimicrobial peptide consists of at least four amino acid residues selected from the group consisting of K,R, and H. Also described are pharmaceutical compositions comprising said antimicrobial peptide and use of the antimicrobial peptide and/or antimicrobial/pharmaceutical composition.
