The present invention relates to a form 1 and form 2 polymorph of (-)-trans -3 -(5,6- dihydro-4H-pyrrolo [3,2,1-ij] quinolin-1-yl)-4-(1H-indol-3-yl) pyrrolidine-2,5-dione. The present invention also relates to (-)-trans-3-(5,6-dihydro-4H-pyrrolo [3,2,1-ij] quinolin-1-yl)-4- (1H-indol-3-yl) pyrrolidine-2, 5-dione compounds having a chiral purity greater than 99%, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising these (-)-trans-3-(5,6-dihydro-4H-pyrrolo [3,2,1-ij] quinolin-l-yl)-4-(lH-indol-3-yl) pyrrolidine-2, 5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a composition comprising (-)-trans- 3-(5,6-dihydro-4H-pyrrolo [3,2,1-ij] quinolin-l-yl)-4-(lH-indol-3-yl) pyrrolidine-2, 5-dione having a chiral purity greater than 99% or a form 1 and form 2 polymorph of (-)-trans -3 -(5,6- dihydro-4H-pyrrolo [3,2,1-ij] quinolin-1-yl)-4-(1H-indol-3-yl) pyrrolidine-2,5-dione.La presente invención se relaciona con una forma 1 y forma 2 polimorfo de (-)-trans-3-(5,6-dihidro-4h-pirrolo [3,2,1-ij] quinolin-1-il)-4-(1H-indol-3-il) pirrolidina-2,5-diona. La presente invención también se relaciona con los compuestos (-)-trans-3-(5,6-dihidro-4H-pirrolo [3,2,1-ij] quinolin-1-il) -4- (1H-indol-3-il) pirrolidina-2, 5-diona que tienen una puridad quiral mayor a 99%, y métodos de preparación de estos compuestos. La presente invención también se relaciona con composiciones farmacéuticas que comprenden estos compuestos (-)-trans-3-(5,6-dihidro-4H-pirrolo [3,2,1-ij] quinolin-1-il) -4- (1H-indol-3-il) pirrolidina-2, 5-diona. La presente invención proporciona métodos de prueba de un trastorno proliferativo celular como el cáncer, mediante la administración a un sujeto con la necesidad del mismo de una cantidad terapéuticamente efectiva de una composición que comprende (-)-
