The inventive retard tablets comprising at least two layers, wherein at leastone layer rapidly releases a drug 1S 9S (RS, 3S) N-(2-Ethoxy-5-oxo- tetrafuran-3-yl)-6, 10-dioxo-9-(isochinolin-1-oyl-amino)-1, 2, 3, 4, 7, 8, 9, 10-octahydro- 6-H-pyridazino [1 , 2-a] [1, 2] diazepin-1-carboxamide and/or thesalts or derivatives thereof and/or acids released therefrom and at least onelayer releases a drug 1S, 9S (RS, 3S) N-(2-Ethoxy-5-oxo-tetrafuran-3-yl)-6,10-dioxo-9-(isochinolin-1-oyl-amino)-1, 2, 3, 4, 7, 8, 9, 10-octahydro-6-H-pyridazino [1, 2-a] [1, 2] diazepin-1-carboxamide and/or the salts orderivatives thereof and/or acids released therefrom in a delayed manner fortreating autoimmune diseases, type I and type II diabetes, rheumatoidarthritis, osteoarthritis and/or psoriasis
