THE INVENTIVE RETARD TABLETS COMPRISING AT LEAST TWO LAYERS, WHEREIN AT LEAST ONE LAYER RAPIDLY RELEASES A DRUG 1S 9S (RS, 3S) N-(2-ETHOXY-5-OXO-TETRAFURAN-3- YL)-6, 10-DIOXO-9-(ISOCHINOLIN-L-OYL-AMINO)-1, 2, 3, 4, 7, 8, 9, 10-OCTAHYDRO-6-H-PYRIDAZINO [1, 2-A] [1, 2] DIAZEPIN-L-CARBOXAMIDE AND/OR THE SALTS OR DERIVATIVES THEREOF AND/OR ACIDS RELEASED THEREFROM AND AT LEAST ONE LAYER RELEASES A DRUG 1S, 9S (RS, 3S) N-(2-ETHOXY-5-OXO-TETRAFURAN-3-YL)-6, 10-DIOXO-9-(ISOCHINOLIN-L-OYL-AMINO)-1, 2, 3, 4, 7, 8, 9, 10-OCTAHYDRO-6-H-PYRIDAZINO [1, 2-A] [1, 2] DIAZEPIN-L-CARBOXAMIDE AND/OR THE SALTS OR DERIVATIVES THEREOF AND/OR ACIDS RELEASED THEREFROM IN A DELAYED MANNER FOR TREATING AUTOIMMUNE DISEASES, TYPE 1 AND TYPE 11 DIABETES, RHEUMATOID ARTHRITIS, OSTEOARTHRITIS AND/OR PSORIASIS.