This invention relates to compounds that inhibit KIR2DL1, 2 and/or 3 polypeptide comprising compounds (e.g., anti-KIR2DL1, 2, and/or 3 antibodies) that neutralize NK cell inhibitory receptors and methods of using such compounds and compositions containing in the treatment and prevention of inflammatory or autoimmune disorders.本發明係關於抑制KIR2DL1、KIR2DL2及/或KIR2DL3多肽之化合物,其包含中和NK細胞抑制性受體之化合物(例如抗-KIR2DL1、抗-KIR2DL2及/或抗-KIR2DL3抗體);以及使用該等化合物及含有該等化合物之組合物治療及預防發炎或自體免疫病症的方法。