The present invention relates to α-amino boronic acid derivatives. These compounds are useful for inhibiting the activity of immunoproteasome (LMP7) and for the treatment and/or prevention of medical contidions affected by immunoproteasome activity such as inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases and cancer.本發明係關於α-胺基硼酸衍生物。此等化合物係適用於抑制免疫蛋白酶體(LMP7)之活性及用於治療及/或預防受免疫蛋白酶體活性影響之醫學病症，諸如炎症性及自體免疫性疾病、神經退行性疾病、增生性疾病及癌症。
