The naphthalene carboxamide derivatives,the preparation methods and the uses thereof. The structureis shown as the formula (I), wherein the definitions ofR1, R2, R3, R4 and Z are the same to those described in thedescription. The compounds have the protein kinase inhibitionactivities and the histone deacetylase inhibition activitiessimultaneously, and can be used for treating diseasesrelated to protein kinase activity abnormity or histonedeacetylase activity abnormity, including inflammation,autoimmune diseases, cancer, nervous system diseasesand neurodegenerative diseases, metabolic diseases,angiocardiopathy, hypersusceptibility, asthma, and diseasesrelated to hormone.
