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Uso de agonistas de receptores de 1-fosfato de esfingosina (s1p) en combinación con un segundo agente para el tratamiento de enfermedades cerebrales degenerativas
专利权人:
NOVARTIS AG
发明人:
BRINKMANN, VOLKER,KANEIDER, NICOLE,WIEDERMANN, CHRISTIAN J.
申请号：
ES09177200
公开号：
ES2444717T3
申请日:
2004.12.17
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A pharmaceutical combination comprising a) a first agent which is 2-amino-2- [2- (4-octylphenyl) ethyl] propane-1,3-diol in free form or in pharmaceutically acceptable salt form, or phosphate FTY720 b) a segundoagente, which is selected from an AMPA receptor agonist, wherein the agonist AMPA receptor is selected from aminoalkylphosphonate quinoxalindiona 7-acetyl-5- (4-aminophenyl) -8,9-dihydro-8-methyl-7H-1,3-dioxolo [4,5-h] [2,3] benzodiazepin-8-carbonitrile 4- (7-chloro-2-methyl-4H-3,10atriazabenzo [f] azulene-9-yl) -phenylamine N, N-dimethyl-2- [2- (3-phenyl-1,2,4-oxadiazol-5-yl) phenoxy] ethanamine 7- [4 - [[[[(4-carboxyphenyl) -amino] carbonyl] oxy] methyl] -1H-imidazol-1-yl] -3,4-dihydro-3-oxo-6- (trifluoromethyl) - 2-quinoxalinecarboxylic salmonosódica of 2 - [[[5- [4 - [(dimethylamino) -sulfonyl] phenyl] -1,2,6,7,8,9-hexahydro-8-methyl-2-oxo-3H-pyrrolo [3 2-10 h] isoquinolin-3-ylidene] amino] oxy] -4-hydroxybutanoic 2,3: 4,5-bis-O- (1-methylethylidene) -beta-Dfructopiranosa (R) -7-acetyl-5- (4-aminophenyl) -8,9-dihydro-8-methyl- 7H-1,3-dioxolo [4,5-h] [2,3] benzodiazepine 6-imidazol-1-yl-7-nitro-1,4-dihydroquinoxaline-2,3-dione -Chloro-6-sulfamoyl-2- 7- (1H) -quinolinon-3-phosphoric acid 7-imidazol-1-yl-6-nitro-2,3-dioxo-3,4-dihydro-2H-quinoxalin-1-yl) -acetic acid 4- (8-methyl-9H-1,3-dioxa-6,7-diaza-cyclohepta [f] inden-5-yl) -phenylamine 7-morpholin-4-yl-2,3-dioxo-6-trifluoromethyl-3,4-dihydro-2H-quinoxalin-1-ylmethyl) ester 3- (2-cloro15fenil) -2- [2- (6-diethylaminomethylpyridin-2-yl) -vinyl] -6-fluoro-3H-quinazolin-4-one propylamide 4- (4-aminophenyl) -6-methoxy-1-methyl-1H-phthalazin-2-carboxylic acid I propylamide 8- (4-aminophenyl) -5-methyl-5H- [1,3] dioxolo acid [4,5-g] phthalazin-6-carboxylic acid acid (4-oxo-2-phosphono-5,10-dihydro-4H-imidazo [1,2-a] indeno [1,2-e] pyrazin-9-yl) -acetic acid and 6- [(1H-tetrazol-5-yl) -ethyl 2-] -decahidroisoquinolin-3-carboxylic. acidUna combinación farmacéutica que comprende a) un primer agente que es 2-amino
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