The peptide consisting of the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2 of the present invention shows the proliferation and differentiation promotion of osteoblasts and the proliferation and activity promoting effect of periodontal ligament fibrillar cells. The peptide of the present invention is ultimately produced by increasing BMP signaling such as smad1 / 5/8 phosphorylation, increasing osteoblast cell growth and expression of differentiation markers such as COL1A1, BSP, ALP It shows bone activity. The peptide of the present invention promotes the growth of periodontal ligament fibroblasts through PI3K and Akt phosphorylation and ultimately increases periodontal tissue regenerating activity by increasing the expression of active markers such as COL1A1 and DSPP . The present invention provides a composition for preventing or treating bone diseases comprising the above-described peptide and a composition for preventing or treating periodontal disease.BACKGROUND OF THE INVENTION本発明の配列番号１または配列番号２のアミノ酸配列からなるペプチドは、造骨細胞の増殖と分化促進、及び歯周靭帯線維母細胞の増殖と活性促進効能を示す。本発明のペプチドは、ｓｍａｄ１／５／８リン酸化のようなＢＭＰシグナリングを増加させ、造骨細胞の成長及びＣＯＬ１Ａ１、ＢＳＰ、ＡＬＰのような分化マーカーの発現を増加させることにより、究極的に造骨活性を示す。本発明のペプチドは、ＰＩ３Ｋ及びＡｋｔリン酸化を通じて、歯周靭帯線維母細胞の成長を促進し、ＣＯＬ１Ａ１及びＤＳＰＰのような活性マーカーの発現を増加させることにより、究極的に歯周組織再生活性を示す。本発明は、上述のペプチドを含む骨疾患の予防または治療用組成物及び歯周疾患の予防または治療用組成物を提供する。【選択図】図３ａ
