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PEPTIDE FAVORISANT LA DIFFÉRENCIATION OSTÉOGÉNIQUE ET L'ACTIVATION DES FIBROBLASTES DU LIGAMENT PARONDONTAL, ET SON UTILISATION
专利权人:
Caregen Co.; Ltd.
发明人:
申请号:
EP14898450.3
公开号:
EP3181145A1
申请日:
2014.08.05
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
A peptide comprising an amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, according to the present invention, shows proliferation and differentiation promotion of osteoblast and proliferation and activation promotion of periodontal ligament fibroblast. A peptide, according to the present invention, increases BMP signaling such as SMAD1/5/8 phosphorylation and increases the growth of osteoblast and the expression of a differentiation marker such as COL1A1, BSP and ALP, thereby ultimately showing osteoblast activation. A peptide, according to the present invention, promotes the growth of periodontal ligament fibroblast by means of PI3K and Akt phosphorylation and increases the expression of an activation marker such as COL1A1 and DSPP, thereby ultimately showing periodontal tissue regeneration activation. Provided are a composition for preventing or treating bone diseases and a composition for preventing or treating periodontal diseases, the compositions comprising the aforementioned peptide.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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