BEADLE, JOHN WILLIAM,FISHER, KERRY,WILKINSON BLANC, CHRISTINE
申请号：
CA2914790
公开号：
CA2914790A1
申请日:
2014.06.12
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present disclosure provides a method of treating a human patient comprising the steps of: systemically administering multiple doses of a parenteral formulation of a replication capable oncolytic adenovirus of subgroup B in a single treatment cycle, wherein the total dose given in each dose is in the range of 1x1010 to 1x1014 viral particles, and wherein each dose of virus is administered over a period of 1 to 90 minutes, for example at a rate of viral particle delivery in the range of 2x1010 particles per minute to 2x1012 particles per minute. The disclosure further extends to formulations of the said oncolytic adenoviruses and combination therapies of the viruses and formulations with other therapeutic agents.
