БИДЛ Джон Уильям (GB),ФИШЕР Керри (GB),УИЛКИНСОН БЛАНК Кристин (GB)
申请号：
RU2015152860
公开号：
RU2015152860A
申请日:
2014.06.12
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
The present disclosure provides a method of treating a human patient comprising the steps of: systemically administering multiple doses of a parenteral formulation of a replication capable oncolytic adenovirus of subgroup B in a single treatment cycle, wherein the total dose given in each dose is in the range of 1×1010 to 1×1014 viral particles, and wherein each dose of virus is administered over a period of 1 to 90 minutes, for example at a rate of viral particle delivery in the range of 2×1010 particles per minute to 2×1012 particles per minute. The disclosure further extends to formulations of the said oncolytic adenoviruses and combination therapies of the viruses and formulations with other therapeutic agents.
