An orthotopic artificial bladder endoprosthesis comprises a casing (2) made of a PGA fiber fabric said casing (2) having two first connectors (3) for the connection with the ureters of a patient and a further connector (4) for the connection with the urethra of a patient an inflatable element (5) inserted in said casing (2) said inflatable element (5) being switchable between an inflated configuration in which it supports and maintains in position the casing (2) and a deflated configuration.