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PROCESS TO MINIMIZE POLYMORPHISM
专利权人:
R.P. SCHERER TECHNOLOGIES; LLC
发明人:
HOWES, SIMON, A
申请号:
NZ58761109
公开号:
NZ587611A
申请日:
2009.02.26
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is a process for preparing an oral, solid fast dispersing dosage form of a pharmaceutically active substance, wherein said substance exhibits polymorphism in an aqueous environment, comprising the steps of: (a) forming a suspension of particles of said substance in a carrier material in a continuous phase, wherein the carrier material comprises standard molecular weight fish gelatin (b) reducing the suspension temperature to less than about 15ºC (c) forming discrete units of the suspension at a formation temperature of less than about 15ºC and (d) removing the continuous phase to leave the suspension of particles in the carrier material.
来源网站:
中国工程科技知识中心
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