EUROPEAN EGYPTIAN PHARMACEUTICAL INDUSTRIES (EEPI);MAHMOUD, Mona Bakr Mohamed;HELMY, Sherine Hassan Abbas;NANOTECH FOR PHOTOELECTRONICS RESEARCH
发明人:
MAHMOUD, Mona Bakr Mohamed,HELMY, Sherine Hassan Abbas
申请号：
EGEG2013/000027
公开号：
WO2014/135170A1
申请日:
2013.10.29
申请国别(地区):
EG
年份:
2014
代理人:
摘要：
New formulas of Iron oxides nanoparticles capped with a mixture of multivitamins such as folic acid, Nicotinic acid (vitamin B9) and Ascorbic acid (vitamin C) has been developed for the rapid and efficient treatment of life threatening iron-deficiency anemia. Small single dose of iron oxides-multivitamin nano-composite as low as 25 mg elemental iron per does is sufficient to increase the hemoglobin level from 4.4 g/dl up to 14.6 g/dl within only four days after administration. The multivitamin which used in this nano-composite enhances iron absorption significantly and elevated the concentration of hemoglobin. Two dosage forms of Iron nano-composites have been developed, gel capsules and aqueous solution for oral administration. Animal trials studies reveal that introducing single dose of Iron Oxide- vitamin nano-composites containing 2.57 mg elemental iron per kg rat body weight (equal to 25 mg in human) is sufficient to correct the hemoglobin level and cure Anemia via oral administration. The toxicity study reveals that the LD50 of our new iron nano-composite is 1425.3 mg/kg rat body weight, means that the LD50 of nano-sized iron nano-composites in standard human (60 kg weight) is 13,854 mg. Thus, the single dose required for rapid treatment of iron deficiency anemia is 554 times less than the LD50 in human. No apparent of any sight of toxicity on hematological, biochemistry or histopathology studies. Moreover, the histopathology study of the bone-marrow suggests that the used iron oxides -vitamin nano-composites increase the number of the RBCs precursors which stimulate the bone- marrow to produce more RBCS.La présente invention concerne de nouvelles formules de nanoparticules d'oxydes de fer coiffées d'un mélange de vitamines multiples telles que l'acide folique, l'acide nicotinique (vitamine B9) et l'acide ascorbique (vitamine C) qui ont été mises au point pour le traitement rapide et efficace d'une anémie liée à une insuffisance en fer mettant en jeu le pronos
