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СПОСОБЫ И КОМПОЗИЦИИ ДЛЯ ПЕРОРАЛЬНОГО ВВЕДЕНИЯ БЕЛКОВ
专利权人:
Интера Био Лтд. (IL)
发明人:
КИДРОН Мириам (IL),АРБИТ Эхуд (US)
申请号:
RU2011108334/15
公开号:
RU2011108334A
申请日:
2009.08.11
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A pharmaceutical composition for oral administration comprising a protein having a molecular weight up to 100,000 daltons protease inhibitor and a compound selected from the group consisting of N- (8- [2-hydroxybenzoyl] amino) caprylate (SNAC), N- (10- [2-hydroxybenzoyl] amino) decanoate (SNAD), salt of SNAC or said SNAD, and combinations thereof. ! 2. A composition according to claim 1, characterized in that said protein is a recombinant protein. ! 3. A composition according to claim 1, characterized in that said compound is a salt of SNAC or said SNAD, and said salt is selected from the group consisting of the monosodium salt, disodium salt and combinations of these salts. ! 4. A composition according to claim 1, characterized in that the said protein is selected from the group consisting of insulin, glucagon, interferon gamma, alpha interferon, growth hormone, erythropoietin, GLP-1, GLP-1 analog, and granulocyte colony stimulating factor (G- CSF). ! 5. A composition according to claim 1, characterized in that said protein is an enzyme. ! 6. A composition according to claim 1, characterized in that said protease inhibitor is selected from the group consisting of serpin, a suicide inhibitor, transition state inhibitor, a protein protease inhibitor, chelating agent, an inhibitor of cysteine ​​proteases, threonine protease inhibitor, an inhibitor of aspartic proteases and an inhibitor metalloprotease. ! 7. A composition according to claim 6, characterized in that said protease inhibitor is a serpin and said serpin is a trypsin inhibitor. ! 8. A composition according to claim 1, characterized in that said protease inhibitor is selected from the group consisting and1. Фармацевтическая композиция для перорального введения, содержащая белок, имеющий молекулярный вес до 100000 Дальтон ингибитор протеаз и соединение, выбранное из группы, состоящей из N-(8-[2-гидроксибензоил]амино)каприлата (SNAC), N-(10-[2-гидроксибензоил]амино)деканоата (SNAD), соли указанного SNAC или
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