The United States of America, as Represented By the Secretary, Deprt. of Health and Human Services;The Brigham and Women's HospitalInc.
发明人:
Paul B. Yu,Wenwei Huang,Philip Edward Sanderson,Jian-Kang Jiang,Khalida Shamim,Wei Zheng,Xiuli Huang,Gregory Tawa,Arthur Lee,Asaf Alimardanov,Junfeng Huang
申请号：
US16608489
公开号：
US20200179389A1
申请日:
2018.04.26
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjögren's syndrome, or diffuse intrinsic pontine glioma (DIPG).
